Investigation of tunable acetalated dextran microparticle platform to optimize M2e-based influenza vaccine efficacy
نویسندگان
چکیده
منابع مشابه
In vitro analysis of acetalated dextran microparticles as a potent delivery platform for vaccine adjuvants.
Toll-like receptor (TLR) agonists induce potent innate immune responses and can be used in the development of novel vaccine adjuvants. However, access to TLRs can be challenging as exemplified by TLR 7, which is located intracellularly in endosomal compartments. To increase recognition and subsequent stimulatory effects of TLR 7, imiquimod was encapsulated in acetalated dextran (Ac-DEX) micropa...
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ژورنال
عنوان ژورنال: Journal of Controlled Release
سال: 2018
ISSN: 0168-3659
DOI: 10.1016/j.jconrel.2018.09.020